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There is reason to be optimistic though.

Not every modern human has the same set of Neanderthal DNA, however; different people will, by chance, have inherited different fragments. But there are also some areas, termed "Neanderthal deserts," where none of the Neanderthal DNA seems to have persisted. Notably, the largest Neanderthal desert is the entire X chromosome, raising questions about whether this reflects the evolutionary fitness of genes there or mating preferences.

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